RESUMO
Glomus tumors are rare hamartomas that originate from the glomus body. These tumors can be divided into solitary and multiple, the latter also known as glomangioma. We report the case of two patients with a rare variety of glomangioma called congenital plaque-like glomangioma. It presents as numerous red to bluish compressible papules, that increase in size in proportion with the weight and height growth of the child. Diagnostic confirmation is with histopathology and the treatment is surgical.
Assuntos
Tumor Glômico/congênito , Tumor Glômico/patologia , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/patologia , Adolescente , Adulto , Feminino , Humanos , Doenças Raras/congênito , Doenças Raras/patologia , Telangiectasia/congênito , Telangiectasia/patologiaRESUMO
No disponible
Assuntos
Humanos , Masculino , Recém-Nascido , Tumor Glômico/cirurgia , Angioplastia a Laser/métodos , Neoplasias Cutâneas/cirurgia , Lasers de Estado Sólido/uso terapêutico , Neoplasias Cutâneas/congênito , Tumor Glômico/congênitoAssuntos
Doenças em Gêmeos/radioterapia , Tumor Glômico/radioterapia , Doenças do Prematuro/radioterapia , Lasers de Corante/uso terapêutico , Lasers de Estado Sólido/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Neoplasias Cutâneas/radioterapia , Estética , Seguimentos , Tumor Glômico/congênito , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Ombro , Neoplasias Cutâneas/congênitoRESUMO
Abstract: Glomus tumors are rare hamartomas that originate from the glomus body. These tumors can be divided into solitary and multiple, the latter also known as glomangioma. We report the case of two patients with a rare variety of glomangioma called congenital plaque-like glomangioma. It presents as numerous red to bluish compressible papules, that increase in size in proportion with the weight and height growth of the child. Diagnostic confirmation is with histopathology and the treatment is surgical.
Assuntos
Humanos , Feminino , Adulto , Neoplasias Cutâneas/congênito , Tumor Glômico/congênito , Tumor Glômico/patologia , Neoplasias Cutâneas/patologia , Telangiectasia/congênito , Telangiectasia/patologia , Doenças Raras/congênito , Doenças Raras/patologiaRESUMO
No disponible
Assuntos
Humanos , Feminino , Criança , Tumor Glômico/congênito , Mosaicismo , Neoplasias Vasculares/congênito , Aberrações CromossômicasRESUMO
Glomovenous malformations are disseminated variants of cutaneous glomus tumors. These malformations are subdivided into regional or localized, disseminated, and congenital plaque-like forms. The congenital plaque-like form is the rarest variant. Most treatment modalities have been disappointing in the treatment of large glomangiomas, leading to high recurrence rates. We report a case of a 34-year-old man with a congenital plaque-like glomangioma on his left arm and forearm treated successfully with sequential pulsed-dye neodymium yttrium aluminum garnet laser.
Assuntos
Tumor Glômico , Terapia a Laser/métodos , Neoplasias Cutâneas , Adulto , Tumor Glômico/congênito , Tumor Glômico/patologia , Tumor Glômico/cirurgia , Humanos , Masculino , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
There are several reports of the collision of vascular and pigmentary anomalies (e.g., phakomatosis pigmentovascularis) and the association between congenital melanocytic nevi and infantile hemangiomas. We report a case of Spitz nevus arising in skin overlying a congenital plaque-like glomuvenous malformation (GVM). This is the first report of a Spitz nevus arising in direct contiguity to a GVM.
Assuntos
Tumor Glômico/complicações , Tumor Glômico/patologia , Nevo de Células Epitelioides e Fusiformes/complicações , Nevo de Células Epitelioides e Fusiformes/patologia , Paraganglioma Extrassuprarrenal/complicações , Paraganglioma Extrassuprarrenal/patologia , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/patologia , Biópsia , Pré-Escolar , Tumor Glômico/congênito , Humanos , Masculino , Paraganglioma Extrassuprarrenal/congênitoRESUMO
Congenital plaque-type glomuvenous malformation (GVM) is caused by loss of function mutations in glomulin gene. We report a newborn with this rare vascular disorder associated with chylous ascites. The common mesenchymal origin of GVM and lymphatic vessels as well as the glomulin expression in vascular smooth muscle cells in utero could help explain this unusual prenatal complication of glomuvenous malformations.
Assuntos
Proteínas Adaptadoras de Transdução de Sinal/genética , Ascite Quilosa/complicações , Ascite Quilosa/genética , Ascite Quilosa/congênito , Feminino , Tumor Glômico/complicações , Tumor Glômico/congênito , Tumor Glômico/genética , Humanos , Recém-Nascido , Vasos Linfáticos/patologia , Vasos Linfáticos/fisiologia , Músculo Liso Vascular/patologia , Músculo Liso Vascular/fisiologia , Paraganglioma Extrassuprarrenal/complicações , Paraganglioma Extrassuprarrenal/congênito , Paraganglioma Extrassuprarrenal/genéticaRESUMO
Multiple congenital glomuvenous malformations (GVMs) are rare. Almost all reported cases describe the multiple congenital plaquelike GVM variant. We report a case of multiple congenital plaquelike GVMs suggestive of type 2 segmental involvement following Blaschko lines.
Assuntos
Tumor Glômico/patologia , Neoplasias Cutâneas/patologia , Feminino , Seguimentos , Tumor Glômico/congênito , Tumor Glômico/diagnóstico , Humanos , Imuno-Histoquímica , Recém-Nascido , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/diagnósticoAssuntos
Tumor Glômico/congênito , Couro Cabeludo/patologia , Neoplasias Cutâneas/congênito , Pré-Escolar , Feminino , Tumor Glômico/patologia , Tumor Glômico/cirurgia , Humanos , Imuno-Histoquímica , Couro Cabeludo/cirurgia , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
Glomus tumours are solitary benign lesions most frequently located subungually on fingers and toes. In the rare case of a glomangiomatosis, the typical glomus cells are found on the altered vessel wall of the angiomatosis. Due to the rarity of this disease, no therapeutic golden standard has been mentioned in the literature, and a conservative treatment is usually adopted. The case of a 20-year-old craftsman with congenital, painful glomangiomatosis on his left dominant hand, progressively limiting the functionality of this limb, is reported. Two years after unsuccessful partial tumour resection, a surgical treatment based on radical tumour resection in terms of a finger amputation was performed. The 1-year follow-up showed no signs of pain for the patient.
Assuntos
Tumor Glômico/cirurgia , Mãos/cirurgia , Neoplasias de Tecidos Moles/cirurgia , Neoplasias Vasculares/cirurgia , Amputação Cirúrgica , Angiografia , Diagnóstico Diferencial , Dedos/irrigação sanguínea , Dedos/patologia , Dedos/cirurgia , Tumor Glômico/congênito , Tumor Glômico/diagnóstico , Tumor Glômico/patologia , Mãos/irrigação sanguínea , Mãos/patologia , Humanos , Angiografia por Ressonância Magnética , Masculino , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/cirurgia , Reoperação , Neoplasias de Tecidos Moles/congênito , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/patologia , Neoplasias Vasculares/congênito , Neoplasias Vasculares/diagnóstico , Neoplasias Vasculares/patologia , Adulto JovemAssuntos
Tumor Glômico/complicações , Hipertricose/complicações , Neoplasias Cutâneas/complicações , Derme/patologia , Tumor Glômico/congênito , Tumor Glômico/patologia , Folículo Piloso/patologia , Humanos , Hipertricose/patologia , Lactente , Masculino , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/patologiaRESUMO
No disponible
No disponible
Assuntos
Feminino , Adulto , Humanos , Tumor Glômico/congênito , Tumor Glômico/complicações , Tumor Glômico/diagnóstico , Telangiectasia/complicações , Telangiectasia/diagnóstico , Imuno-Histoquímica/métodos , Escápula , DesminaRESUMO
BACKGROUND: Glomuvenous malformations (GVMs) are now considered a separate entity from venous malformations. The rarest type of GVM is the generalized congenital plaque-type GVM. OBSERVATIONS: We present 10 new cases of congenital plaque-type GVM and describe their clinical progression and treatment. Mutations in the glomulin gene were found in those patients who participated in the genetic study. CONCLUSIONS: Congenital plaque-type GVMs are unique in their congenital nature, extensive distribution, difficult to diagnose and treat, and progressive involvement after birth. Most cases are familial, yet affected relatives usually have only minor lesions. The lesions of congenital plaque-type GVM are severe, visible at birth, and usually mistaken for extensive venous malformations. Vascular malformations are divided by hemodynamic type into slow-flow and fast-flow lesions. Slow-flow lesions are subcategorized as capillary, lymphatic, and venous.(1) Capillary malformations are flat, sharply demarcated, red-pink vascular stains of the skin commonly referred to as port-wine stains. These persist throughout life and are characterized histologically by dilated capillaries within the dermis. They slowly increase in size with age. Lymphatic malformations are spongelike collections of abnormal channels and spaces that contain clear lymphatic fluid, causing an excess of fluid to accumulate and dilate the lymphatic channels. This results in swelling of the affected area and, if extensive, can cause enlargement of soft tissues and bones.
Assuntos
Tumor Glômico/diagnóstico , Neoplasias Cutâneas/diagnóstico , Proteínas Adaptadoras de Transdução de Sinal/genética , Adolescente , Adulto , Criança , Diagnóstico Diferencial , Feminino , Predisposição Genética para Doença , Tumor Glômico/congênito , Tumor Glômico/genética , Tumor Glômico/patologia , Humanos , Lactente , Recém-Nascido , Masculino , Mutação , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/patologiaRESUMO
A 13 year old girl presented with recurrent painful "varicosities" on her right calf. These lesions were subsequently clinically diagnosed as "cavernous haemangiomas" after normal duplex scanning and were excised. Histological examination revealed multiple glomangiomas (glomus tumours). A literature review revealed only two reported cases of nodular multiple glomangioma, so that this is the third case to be reported in the literature.
